Faculty: Graduate School of Health Science This major focuses on the study of the adverse effects of drugs and other chemicals on living organisms. Students develop a deep understanding of toxicological principles, drug safety, and the mechanisms of toxicity. Graduates are prepared for careers in pharmaceutical research, regulatory affairs, and healthcare industries. **Learning Objectives:** - Understand the fundamentals of toxicology, including principles, mechanisms, and risk assessment. - Develop skills in evaluating drug safety, conducting toxicological studies, and interpreting toxicity data. - Learn techniques for assessing the adverse effects of drugs and chemicals on biological systems. - Explore principles of pharmacokinetics, metabolism, and the molecular basis of toxicity. - Analyze and interpret complex toxicological data and regulatory guidelines. - Develop critical thinking, problem-solving, and analytical skills for pharmaceutical research and regulatory affairs. **Major Outline:** 1. **Introduction to Pharmaceutical Toxicology** - Overview of key concepts, principles, and research methods in toxicology. - Fundamentals of drug safety, adverse effects, and risk assessment. 2. **Principles of Toxicology** - Principles of toxicology, including dose-response relationships, mechanisms of toxicity, and toxicokinetics. - Techniques for conducting and interpreting toxicological studies. 3. **Pharmacokinetics and Drug Metabolism** - Fundamentals of pharmacokinetics, drug absorption, distribution, metabolism, and excretion. - Techniques for studying drug metabolism and the molecular basis of toxicity. 4. **Organ-Specific Toxicology** - Principles of organ-specific toxicology, including hepatotoxicity, nephrotoxicity, and neurotoxicity. - Techniques for evaluating the adverse effects of drugs on specific organs. 5. **Genetic Toxicology** - Fundamentals of genetic toxicology, mutagenesis, and carcinogenesis. - Techniques for assessing the genetic and carcinogenic potential of drugs and chemicals. 6. **Regulatory Toxicology** - Principles of regulatory toxicology, safety guidelines, and regulatory compliance. - Techniques for preparing and submitting regulatory documents and safety assessments. 7. **Clinical Toxicology** - Fundamentals of clinical toxicology, poisoning, and emergency treatment. - Techniques for managing and treating drug overdoses and poisoning cases. 8. **Research Methods in Toxicology** - Principles of research methods, experimental design, and data analysis in toxicology. - Techniques for conducting and presenting toxicological research. 9. **Practicum in Pharmaceutical Toxicology** - Real-world experiences in pharmaceutical toxicology, including observations, internships, and hands-on projects in research labs, pharmaceutical companies, or regulatory agencies. - Application of learned skills in practical toxicology scenarios. 10. **Capstone Project in Pharmaceutical Toxicology** - Comprehensive project applying skills in toxicological research, drug safety evaluation, or regulatory affairs. - Delivery of a polished research project, toxicity study, or regulatory submission. **Assessment Methods:** - Research papers, toxicological studies, pharmacokinetic analyses, organ-specific toxicity reports, genetic toxicology evaluations, regulatory compliance documents, clinical toxicology case studies, research methodology projects, practicum reports, capstone projects, group projects, and internship evaluations. **Recommended Textbooks:** - "Casarett and Doull's Toxicology: The Basic Science of Poisons" by Curtis D. Klaassen. - "Principles of Pharmacokinetics and Pharmacodynamics" by Milo Gibaldi and Donald Perrier. - "Genetic Toxicology" by various authors. - "Regulatory Toxicology" by various authors. - "Clinical Toxicology" by various authors. - "Research Methods in Toxicology" by various authors. **Prerequisites:** Basic knowledge of biology, chemistry, and pharmacology. Suitable for students interested in pharmaceutical toxicology, drug safety, and regulatory affairs. **Major Duration:** Typically 4 years for a bachelor's degree, including coursework, projects, practicum, and internships. **Certification:** Graduates may receive a degree in Pharmaceutical Toxicology and pursue further education or professional certifications in related fields, such as a Master's or Ph.D. in Toxicology, Pharmacology, or related disciplines. **Target Audience:** Aspiring toxicologists, pharmacologists, regulatory affairs specialists, and individuals seeking careers in pharmaceutical research, regulatory agencies, healthcare industries, and related fields. This major equips students with the theoretical, experimental, and analytical skills needed to excel in pharmaceutical toxicology, supporting careers in pharmaceutical research, regulatory affairs, healthcare industries, and related fields.